Name: Jin, Li Hua

Degree: Ph.D

Title: Professor

Position:

Phone number: 86-451-8219-0242

E-mail: lhjin@nefu.edu.cn；lhjin2000@hotmail.com

Address: Northeast Forestry University, Shaw (Yifu) Teaching Building, Room 254

Education and Training:

      1989 – 1993: YanBian University, Bachelor of Chemistry

      1998 – 2000: Kangwon University, Master of Applied biology and technology

      2000 – 2003: Hallyme University, Ph.D. in Biomedical Gerontology

      2003 – 2005: Yonsei University, Postdoctoral Training in Biochemistry, Genome Regulation Center,

Employment:

      2005 – 2009: Yonsei University, Research Professor

2009 – 2023: Northeast Forestry University, Department of Genetics, Professor

2023–2023: Northeast Forestry University, Professor

Honors and Awards:

      2013: China forestry Youth Science and Technology Award

Research Specialty:

Molecular Biology, Cell biology, Immunology

Courses to Teach:

Genetics, The modern genetics, Subject on Genetics

Extramural Appointments and Service:

2013-2023: Scientific Reviewer of National Natural Science Foundation of China

Research Interest:

The development and specification of blood cells in Humans and Drosophila are controlled by conserved transcriptional regulators and signaling pathways. Drosophila has become a good model for investigating the genetic and molecular mechanisms of life Science and Human disease, especially hematopoiesis and associated leukemias. My research interest is Drosophila innate immunity, Hematopoiesis, gut immunity and pharmacology of traditional medicine field.

Funding:

(1) National Natural Science Foundation of China (32170484)      (P.I.)      

01/01/2022 – 12/31/2025

Title: Regulatory mechanism of Drosophila Rab1 in maintaining homeostasis of hematopoietic stem cells

(2) National Natural Science Foundation of China (31772521)      (P.I.)      

01/01/2018 – 12/31/2021

Title: The molecular mechanism of Rab5 in Drosophila hematopoiesis

(3) Natural Science Foundation of Heilongjiang Province,China (C2016010)  (P.I.)

07/01/2016 – 06/30/2019

Title: Effects of medicinal plants on Drosophila intestinal immunity and insulin metabolism

(4) Specialized Research Fund for the Doctoral Program of Higher Education of China (20130062110011)  (P.I.)

01/01/2014 – 12/31/2016

Title: Mechanisms of Foxn1 regulating cellular immune response in Drosophila

(5) National Natural Science Foundation of China (31270923)      (P.I.)      

01/01/2013 – 12/31/2016

Title: The role of transcription factor jumu in Drosophila cellular immunity

(6) Scientific Research Starting Foundation for Returned Overseas Chinese Scholars, Ministry of Education, China. (P.I.)

01/01/2012 – 12/31/2014

Title: Functional analysis of immune related genes in Drosophila

(7) Scientific Research Foundation of the State Human Resource Ministry and the Education Ministry for Returned Chinese Scholars, China (Grant No. ) (P.I.) 01/01/2011 – 12/31/2013

Title: Functional analysis of CG7510 in Drosophila innate immunity

(8) National Natural Science Foundation of  China (31070775) (P.I.)

01/01/2011 – 12/31/2013

Title: Function and molecular mechanism of CG7510 in Drosophila innate immunity

(9) National Natural Science Foundation of China (30940063)      (P.I.)      

01/01/2010 – 12/31/2010,

Title: Function and molecular mechanism of immune related genes in Drosophila

Publications:

1.  Bo Qin†, Shichao Yu†, Qiming Chen, Li Hua Jin*. Atg2 Regulates Cellular and Humoral Immunity in Drosophila. (2023) Insects. 14;14(8):706.

2. Wenhao Zhang, Wang D, Si J, Li Hua Jin*, Yangguang*. (2023) Gbb Regulates Blood Cell Proliferation and Differentiation through JNK and EGFR Signaling Pathways in the Drosophila Lymph Gland. Cells. 19;12(4):661.

3. Shichao Yu†, Fangzhou Luo†, Yongyi Xu, Yan Zhang, Li Hua Jin* Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues. (2022) Frontiers in immunology. 13:905370.

4. Xue Lei, Ziqian Zhou, Sihong Wang, Li Hua Jin* The protective effect of safranal against intestinal tissue damage in Drosophila. (2022) Toxicology and Applied Pharmacology. 439:115939.

5. Jiewei Wang, Qiang Liu, Yuan Gong, Li Hua Jin*. Anchor maintains gut homeostasis by restricting the JNK and Notch pathways in Drosophila. (2021) Journal of Insect Physiology. 134: 104309.

6. Shichao Yu, Fangzhou Luo, Li Hua Jin*. Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila. (2021) Elife. 10:e60870.

7. Fangzhou Luo, Shichao Yu, Li Hua Jin*. The Posterior Signaling Center Is an Important Microenvironment for Homeostasis of the Drosophila Lymph Gland. (2020) Frontiers in Cell and Developmental Biology. 8:382.

8. Hong Zhang, Sihong Wang, Li Hua Jin*. A canthopanax senticosus polysaccharide regulates the proliferation and differentiation of Drosophila intestinal stem cells. (2020) Phytotherapy Research. 34:193-200.

9. Xiaochun Wang, Ziguang Liu, Li Hua Jin*. Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development. (2019) Apoptosis. 24:465-477.

10. Yangguang Hao, Shichao Yu, Fangzhou Luo, Li Hua Jin*. Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila. (2018) Cell Communication and Signaling. 5;16:95.

11. Xiao Chun Wang, Ziguang Liu , Li Hua Jin*. Anchor negatively regulates BMP signalling to control Drosophila wing development. (2018) European Journal of Cell Biology. 97:308-317.

12. Shichao Yu, Gaoqun Zhang, Li Hua Jin*. A high-sugar diet affects cellular and humoral immune responses in Drosophila. (2018) Experimental cell research. 15;368:215-224.

13. Shichao Yu, Fangzhou Luo, Li Hua Jin*. The Drosophila lymph gland is an ideal model for studying hematopoiesis. (2018) Developmental and Comparative Immunology. 83:60-69.

14. Qiang Liu and Li Hua Jin*. The zinc finger protein CG12744 is essential for differentiation and regeneration after infection in the adult Drosophila midgut. (2017) Experimental Cell Research. 361:225-235.

15. Qiang Liu and Li Hua Jin*. Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract. (2017) Cell Communication and Signaling.  18;15:33.

16. Qiang Liu and Li Hua Jin*. Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective. (2017) Frontiers in Cell and Developmental Biology. 3;5:29.

17. Xiaoyue Zhang, Qiuxia Jin, Li Hua Jin*. High sugar diet disrupts gut homeostasis though JNK and STAT pathways in Drosophila. (2017) Biochemical and Biophysical Research Communications. 487: 910-916.

18. Yangguang Hao, Li Hua Jin*. Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland. (2017) eLife. 6:e25094.

19. Gaoqun Zhang, Yangguang Hao, Li Hua Jin*. Overexpression of jumu induces melanotic nodules by activating Toll signaling in Drosophila. (2016) Insect Biochem Mol Biol. 77:31-38.  

20. Yang Zhou, Zonglin Liu, Yuchen Chen, Li Hua Jin*. Identification of protective effects of traditional medicinal plants against SDS-induced Drosophila gut damage. (2016) Experimental and Therapeutic Medicine. 12:2671-2680

21. Weiyu Zhang, Li Hua Jin. Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents. (2016) Evid Based Complement Alternat Med. 2016:7603746.

22. Jichuan Pan, Li Hua Jin*. rgn gene is required for gut cell homeostasis after ingestion of sodium dodecyl sulfate in Drosophila. (2014) Gene. 549(1):141-148.  

23. Caixia Zhu, Fachun Guan, Chao Wang, Li Hua Jin*. The Protective Effects of Rhodiola  crenulata Extracts on Drosophila melanogaster Gut Immunity Induced by Bacteria and SDS Toxicity. (2014) Phytotherapy Research. 28:1861-1866.

24. Wenjia Li, Qiuxiang Luo, Li Hua Jin*. Acanthopanax senticosus extracts have a protective effect on Drosophila gut immunity. (2013) Journal of Ethnopharmacology. 146(1):257-263.