Name: Song, Wei
Degree: Ph.D.
Title: Associate Professor
E-mail: songw@nefu.edu.cn
Address:Northeast Forestry University, Shaw (Yifu) Teaching Building, Room 504
Education and Training:
2007 – 2011: Northwest A&F University, Bachelor of Agriculture in Biology
2012 – 2019: Wuhan University, Ph.D. in Botany
2019 – 2022: Zhejiang Chinese Medical University, Postdoctoral Training in
Pharmacy
Employment:
2022 –: Northeast Forestry University, Associate Professor
Research Specialty:
(Plant secondary metabolism, Enzyme catalysis, Synthetic Biology)
Research Interest:
My research focuses on the metabolism and regulatory network of steroidal saponin in plants, examining the key genes in the synthetic pathways as well as the differences in bioactivities caused by structural changes of small molecules. Meanwhile, I'm working on improving the catalytic efficiency of P450 cytochrome monooxygenases, α-ketoglutarate dependent dioxygenases, and UDP-glycosyltransferases involved in steroid modification through rational design and other means. To employ synthetic biology strategies to build steroid metabolic pathways in plant or microbial chassis in order to produce natural or non-natural steroids.
Funding:
(1)General project of National Natural Science Foundation of China (Principal investigator), Title: Insight into the molecular mechanism and biological function of the diverse oxidative modification of steroidal saponins inParis polyphylla, 01/01/2024 – 12/31/2027 (32370381).
(2)Outstanding Youth Fund of National Natural Science Foundation of Heilongjiang, China (Principal investigator), Title: Heterologous and efficient synthesis of polyphyllin using yeast and tobacco chassis, 07/01/2023 – 07/01/2026 (YQ2023C021).
(3)Youth Fund of National Natural Science Foundation of China (Principal investigator), Title: Unraveling the glycosylation mechanism of steroidal sapogenin fromParis Polyphylla, 01/01/2022 – 12/31/2024 (32100210).
Publications:
Xue Yin#, Jia Liu#, Chengxi Kou#, Jiaojiao Lu, He Zhang,Wei Song*, Yuhua Li*, Zheyong Xue*, Xin Hua*. (2023) Deciphering the network of cholesterol biosynthesis inParis polyphyllalaid a base for efficient diosgenin production in plant chassis.Metabolic Engineering, 76: 232-246.
https://doi.org/10.1016/j.ymben.2023.02.009
Wei Song#, Chunchun Zhang#, Jiali Wu, Jianzhao Qi, Xin Hua, Liping Kang*, Qiang Yuan*, Jifeng Yuan*, Zheyong Xue*. (2022) Characterization of threeParis polyphyllaglycosyltransferases from different UGT families for steroid functionalization.ACS Synthetic Biology11(4): 1669-1680.
https://doi.org/10.1021/acssynbio.2c00103
Xin Hua#,Wei Song#, Kangzong Wang#, Xue Yin, Changqi Hao, Zhichao Xu*, Tongbing Su*, Zheyong Xue*. (2022) Effective prediction of biosynthetic pathway genes involved in bioactive polyphyllins inParis polyphylla.Communications Biology5:50.
https://doi.org/10.1038/s42003-022-03000-z
Qiwen Mo,Wei Song, Zheyong Xue*, Jifeng Yuan*. (2022) Multi-level engineering ofSaccharomyces cerevisiaefor the synthesis and accumulation of retinal.Green Chemistry24: 8259-8263.
https://doi.org/10.1039/D2GC03073J
Wei Song, Shan Yan, Yi Li, Shan Feng, Jiajiao Zhang, Jiaru Li. (2019) Functional characterization of squalene epoxidase and NADPH-cytochrome P450 reductase inDioscorea zingiberensis.Biochemical and Biophysical Research Communications509(3): 822-827.
https://doi.org/10.1016/j.bbrc.2019.01.010
