Home > Faculty Members > Content

Song, Wei

Time:2023-12-08Source: ClickTimes:

Name: Song, Wei

Degree: Ph.D.

Title: Associate Professor

E-mail: songw@nefu.edu.cn

Address:Northeast Forestry University, Shaw (Yifu) Teaching Building, Room 504

Education and Training:

2007 – 2011: Northwest A&F University, Bachelor of Agriculture in Biology

2012 – 2019: Wuhan University, Ph.D. in Botany

2019 – 2022: Zhejiang Chinese Medical University, Postdoctoral Training in

Pharmacy

Employment:

2022 –: Northeast Forestry University, Associate Professor

Research Specialty:

(Plant secondary metabolism, Enzyme catalysis, Synthetic Biology)

Research Interest:

My research focuses on the metabolism and regulatory network of steroidal saponin in plants, examining the key genes in the synthetic pathways as well as the differences in bioactivities caused by structural changes of small molecules. Meanwhile, I'm working on improving the catalytic efficiency of P450 cytochrome monooxygenases, α-ketoglutarate dependent dioxygenases, and UDP-glycosyltransferases involved in steroid modification through rational design and other means. To employ synthetic biology strategies to build steroid metabolic pathways in plant or microbial chassis in order to produce natural or non-natural steroids.

Funding:

(1)General project of National Natural Science Foundation of China (Principal investigator), Title: Insight into the molecular mechanism and biological function of the diverse oxidative modification of steroidal saponins inParis polyphylla, 01/01/2024 – 12/31/2027 (32370381).

(2)Outstanding Youth Fund of National Natural Science Foundation of Heilongjiang, China (Principal investigator), Title: Heterologous and efficient synthesis of polyphyllin using yeast and tobacco chassis, 07/01/2023 – 07/01/2026 (YQ2023C021).

(3)Youth Fund of National Natural Science Foundation of China (Principal investigator), Title: Unraveling the glycosylation mechanism of steroidal sapogenin fromParis Polyphylla, 01/01/2022 – 12/31/2024 (32100210).

Publications:

Xue Yin#, Jia Liu#, Chengxi Kou#, Jiaojiao Lu, He Zhang,Wei Song*, Yuhua Li*, Zheyong Xue*, Xin Hua*. (2023) Deciphering the network of cholesterol biosynthesis inParis polyphyllalaid a base for efficient diosgenin production in plant chassis.Metabolic Engineering, 76: 232-246.

https://doi.org/10.1016/j.ymben.2023.02.009

Wei Song#, Chunchun Zhang#, Jiali Wu, Jianzhao Qi, Xin Hua, Liping Kang*, Qiang Yuan*, Jifeng Yuan*, Zheyong Xue*. (2022) Characterization of threeParis polyphyllaglycosyltransferases from different UGT families for steroid functionalization.ACS Synthetic Biology11(4): 1669-1680.

https://doi.org/10.1021/acssynbio.2c00103

Xin Hua#,Wei Song#, Kangzong Wang#, Xue Yin, Changqi Hao, Zhichao Xu*, Tongbing Su*, Zheyong Xue*. (2022) Effective prediction of biosynthetic pathway genes involved in bioactive polyphyllins inParis polyphylla.Communications Biology5:50.

https://doi.org/10.1038/s42003-022-03000-z

Qiwen Mo,Wei Song, Zheyong Xue*, Jifeng Yuan*. (2022) Multi-level engineering ofSaccharomyces cerevisiaefor the synthesis and accumulation of retinal.Green Chemistry24: 8259-8263.

https://doi.org/10.1039/D2GC03073J

Wei Song, Shan Yan, Yi Li, Shan Feng, Jiajiao Zhang, Jiaru Li. (2019) Functional characterization of squalene epoxidase and NADPH-cytochrome P450 reductase inDioscorea zingiberensis.Biochemical and Biophysical Research Communications509(3): 822-827.

https://doi.org/10.1016/j.bbrc.2019.01.010

关闭 打印责任编辑:闫绍鹏

友情链接