Name: Li Lixin
Degree: Ph.D.
Title: Professor
E-mail: lixinli0515@nefu.edu.cn
Address: Northeast Forestry University, Shaw (Yifu) Teaching Building, Room 421B
Education and Training:
1987 – 1991: Northeast Normal University, Bachelor of Science in Biology
2003 – 2005: Kyoto University, Master of Science in Molecular Cell Biology
2005 – 2008: Kyoto University, Ph.D. of Science in Molecular Cell Biology
2009 – 2012: King Abdullah University of Science and Technology, Postdoctoral Training in Molecular Biology in Stress Resistance and Gene Editing Techniques
Employment:
1991 – 2000: Harbin No.1 Middle School, Teacher
2008 – 2010: Northeast Forestry University, Associate Professor
2010 – Present: Northeast Forestry University, Professor
Honors and Awards:
2008: China Outstanding International Student Award
Research Specialty:
1. Plant development mechanisms under stress conditions; 2. The synthesis mechanism and application of plant active substances; 3. Interaction between plants and microorganisms under stress conditions.
Courses to Teach:
Molecular biology, Plant developmental biology, Frontiers in stress molecular biology, Plant Metabolism and Regulation
Extramural Appointments and Service:
2009-present: Scientific Reviewer of National Natural Science Foundation of China
2020-present: Supervisor of Heilongjiang Provincial Society of Cell Biology
2023- : Secretary of Northeast Mountain Wild Vegetable Industry National Innovation alliance
Research Interest:
My research interest is Epigenetic Regulation in Cancer Biology, with the focuses on functional studies of novel oncogenes and tumor suppressors. My previous work suggested an oncogenic role of Yin Yang 1 (YY1) through negatively regulating p53 and p27 tumor suppressors and the regulation is independent of YY1’s transcriptional activity. Currently, my research team is also working on other proteins that play important roles in oncogenesis, including SOX7, DMP1 and noncoding RNAs
Funding:
(1)National Natural Science Foundation of China (32170279) (P.I.)
01/01/2022 – 12/31/2025
Title: Cellular pH and ion homeostasis regulation mechanisms regulated by membrane vesicle transport factor AtSYP71 under saline-alkali stress
(2)National Natural Science Foundation of China (31570246) (P.I.)
01/01/2016 – 12/31/2019
Title: Effects ofArabidopsisMAG2 and Homologous Protein MAL on Polar Transport of Auxin
(3)National Natural Science Foundation of China (30970223) (P.I.)
01/01/2010 – 12/31/2013
Title: Functional analysis of AtUfe1 on storage protein transport in seed cells
(4)National Natural Science Foundation of China (30840002) (P.I.)
01/01/2009 – 12/31/2009
Title: Functional analysis of ER-SNAREs in transport of seed storage proteins
(5) National Natural Science Foundation of Heilongjiang, China (C2016002)
01/01/2016 – 12/31/2018
Title: Functional analysis of AtSly1 on storage protein transportation
Publications:
Li Zhuo, Chen Huan, Guan Qingjie*,LiLixin*, Xuan Yuan Hu*.Gibberellic acid signaling promotes resistance to saline-alkaline stress by increasing the uptake of ammonium in rice. (2023)Plant Physiology and Biochemistry. Accepted
Qian Guangtao, Meng Xiangxiao, Wang Sifan, Mi Yaolei, Qin Zhenfen, Liu Tingxia, Zhang Yiming, Wan Huihua, Chen Weiqiang, Sun Wei, Cao Xue *,Li Lixin*Genome-wide identification of HSF gene family and their expression analysis in vegetative tissue of young seedlings of hemp under different light treatments(2023)Industrial Crops and Products, Nov 204(15):117375. doi.org/10.1016/j.indcrop.2023.117375
Wang M, Zhang H, Zhao X, Zhou J, Qin G, Liu Y, Kou X, Zhao Z, Wu T, Zhu JK, Feng X.,Li Lixin*SYNTAXIN OF PLANTS81 regulates root meristem activity and stem cell niche maintenance via ROS signaling.(2023).Plant Physiol.Feb 12;191(2):1365-1382. doi: 10.1093/plphys/kiac530.
Qian G., Li X., Zhang H., Zhang H., Zhou J., Ma X., Sun W., Yang W., He R., Wahab A., Wan H.,Li Lixin*.Metabolomics analysis reveals the accumulation patterns of flavonoids and phenolic acids in quinoa (Chenopodium quinoa Willd.) grains of different colors.(2023).Food Chemistry. X.Feb 6:17:100594. Doi: org/10.1016/j.fochx.2023.100594
Liu Yuqi, Wang Mingyu, Huang Yongshun, Zhu Peng, Qian Guangtao, Zhang Yiming,Li Lixin*.Genome-Wide Identification and Analysis of R2R3-MYB Genes Response to Saline-Alkali Stress in Quinoa.(2023)Int. J. Mol. Sci.,May 23;24(11):9132. doi: 10.3390/ijms24119132.
Zhang H, Zhou J, Kou X, Liu Y, Zhao X,Qin G, Wang M, Qian G, Li W, Huang Y, Wang X, Zhao Z, Li S, Wu X, Jiang L, Feng X, Zhu J-K andLi Lixin*.Syntaxin of plants71 plays essential roles in plant development and stress response via regulating pH homeostasis.(2023)Front. Plant Sci.Jun 5:14:1198353. doi: 10.3389/fpls.2023.1198353.
Wang, X.; Wang, M.; Huang, Y.; Zhu, P.; Qian, G.; Zhang, Y.; Liu, Y.; Zhou, J.;Li Lixin*.Genome-Wide Identification and Analysis of Stress Response of Trehalose-6-Phosphate Synthase and Trehalose-6-Phosphate Phosphatase Genes in Quinoa.(2023)Int. J. Mol. Sci., Apr 9;24(8):6950. doi: 10.3390/ijms24086950.
Qian G., Wang M., Wang X., Liu K., Li Y., Bu Y. andLi Lixin*.Integrated Transcriptome and Metabolome Analysis of Rice Leaves Response to High Saline–Alkali Stress.(2023).Int. J. Mol. Sci., Feb 17;24(4):4062. doi: 10.3390/ijms24044062.
Li S,Li Lixin*, Wang Z*, Sun J, Zhang H.Impacts of Corn Straw Compost on Rice Growth and Soil Microflora under Saline-Alkali Stress. (2023)Agronomy, 13(6): 1525.doi: 10.3390/agronomy13061525.
Ma X., Zhao X., Zhang H., Zhang Y., Sun S., Li Y., Long Z., Liu Y., Zhang X., Li R., Tan L., Jiang., Zhu J–K. andLi Lixin*MAG2 and MAL Regulate Vesicle Trafficking and Auxin Homeostasis With Functional Redundancy.(2022).Frontiers in Plant Science.Mar 16:13:849532. doi: 10.3389/fpls.2022.849532.
Guan Li, Yang Shurui, Li Shenglin, Liu Yu, Liu Yuqi, Yang Yi, Qin Guochen, Wang Haihai, Wu Tao, Wang Zhigang, Feng Xianzhong, Wu Yongrui, Zhu JianKang., Li Xugang,Li Lixin*.AtSEC22 Regulates Cell Morphogenesis via Affecting Cytoskeleton Organization and Stabilities.(2021).Frontiers in Plant Science.Jun 4:12:635732. doi: 10.3389/fpls.2021.635732.
Zhao X., Guo X., Tang X., Zhang H., Wang M., Kong Y., Zhang X., Zhao Z., Lv M. andLi Lixin*.Misregulation of ER-Golgi Vesicle Transport Induces ER Stress and Affects Seed Vigor and Stress Response.(2018).Frontiers in Plant Science.May 18:9:658. doi: 10.3389/fpls.2018.00658.
Zhang Chunlei, Yu Zipeng, Zhang Mengyue, Li Xiaoxuan, Wang Mingjing,Li Lixin,Li Xugang, Ding Zhaojun, and Tian Huiyu.Serratia marcescens PLR enhances lateral root formation through supplying PLR-derived auxin and enhancing auxin biosynthesis in Arabidopsis.(2022)Journal of Experimental BotanyJun 2;73(11):3711-3725. doi: 10.1093/jxb/erac074.
Tang LP, Yang Y, Wang H,Li Lixin,Liu L, Liu Y, Yuan J, Zhao XY, Palme K, Su YH, Li X.AtNSF regulates leaf serration by modulating intracellular trafficking of PIN1 in Arabidopsis thaliana.(2020)J Integr Plant Biol.Dec 2;63(4):737-755. doi: 10.1111/jipb.13043.
Butt H, Piatek A,Li Lixin, S N Reddy A, M Mahfouz M.Multiplex CRISPR Mutagenesis of the Serine/Arginine-Rich (SR) Gene Family in Rice.(2019)Genes (Basel). Aug 7;10(8):596. doi: 10.3390/genes10080596.
Ling Y, Alshareef S, Butt H, Lozano-Juste J,Li Lixin,Galal AA, Moustafa A, Momin AA, Tashkandi M, Richardson DN, Fujii H, Arold S, Rodriguez PL, Duque P, Mahfouz MM.Pre-mRNA splicing repression triggers abiotic stress signaling in plants. (2017)Plant Journal.Jan;89(2):291-309. doi: 10.1111/tpj.13383.
Ali Z, Abul-faraj A,Li Lixin, Ghosh N, Piatek M, Mahjoub A, Aouida M, Piatek A, Baltes NJ, Voytas DF, Dinesh-Kumar S, Mahfouz MM.Efficient Virus-Mediated Genome Editing in Plants Using the CRISPR/Cas9 System.(2015)Molecular Plant.Aug;8(8):1288-91. doi: 10.1016/j.molp.2015.02.011.
Li Lixin, Shimada Tomoo, Takahashi H, Koumoto Y, Shirakawa M, Takagi J, Zhao X, Tu B, Jin H, Shen Z, Han B, Jia M, Kondo M, Nishimura M, Hara-Nishimura I.MAG2 and three MAG2 INTERACTING PROTEINs form an ER-localized complex to facilitate the storage protein transport in Arabidopsis thaliana.Plant Journal(2013) Dec;76(5):781-91. doi: 10.1111/tpj.12347.
Lixin Li; Ahmed Atef; Agnieszka Piatek; Zahir Ali; Marek Piatek; Mustapha Aouida; Altanbadralt Sharakuu; Ali Mahjoub; Guangchao Wang; Suhail Khan; Nina V. Fedoroff; Jian-Kang Zhu; Magdy M. Mahfouz*.Characterization and DNA Binding Specificities of Ralstonia TAL-like(2013).Molecular Plant.Jul;6(4):1318-30. doi: 10.1093/mp/sst006.
Li Lixin, Atef A, Piatek A, Ali Z, Piatek M, Aouida M, Sharakuu A, Mahjoub A, Wang G, Khan S, Fedoroff NV, Zhu JK, Mahfouz MM.Characterization and DNA-binding specificities of Ralstonia TAL-like effectors.(2013)Molecular Plant.Jul;6(4):1318-30. doi: 10.1093/mp/sst006.
Li Lixin, Piatek MJ, Atef A, Piatek A, Wibowo A, Fang X, Sabir JS, Zhu JK, Mahfouz MM.Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification.(2012)Plant Mol Biol.Mar;78(4-5):407-16. doi: 10.1007/s11103-012-9875-4.
Mahfouz MM,Li Lixin.TALE nucleases and next generation GM crops.(2011)GM Crops.Apr-Jun;2(2):99-103. doi: 10.4161/gmcr.2.2.17254.
Piatek A, Ali Z, Baazim H,Li Lixin,Abulfaraj A, Al-Shareef S, Aouida M, Mahfouz MM.RNA-guided transcriptional regulation in planta via synthetic dCas9-based transcription factors.(2015)Plant Biotechnology J.May;13(4):578-89. doi: 10.1111/pbi.12284.
Mahfouz MM,Li Lixin,Piatek M, Fang X, Mansour H, Bangarusamy DK, Zhu JK.Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein.(2012)Plant Mol Biol.Feb;78(3):311-21. doi: 10.1007/s11103-011-9866-x.
Aouida M,Li Lixin,Mahjoub A, Alshareef S, Ali Z, Piatek A, Mahfouz MM.Transcription activator-like effector nucleases mediated metabolic engineering for enhanced fatty acids production in Saccharomyces cerevisiae.(2015)J Biosci Bioeng.Oct;120(4):364-71. doi: 10.1016/j.jbiosc.2015.02.017.
Mahfouz MM,Li Lixin,Shamimuzzaman M, Wibowo A, Fang X, Zhu JK.De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. (2011)Proc Natl Acad Sci U S A.Feb 8;108(6):2623-8. doi: 10.1073/pnas.1019533108.
Li Lixin, Shimada T., Takahashi H., Ueda H., Fukao Y., Kondo M., et al.MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana.(2006) .Plant Cell18, 3535–3547. doi: 10.1105/tpc. 106.046151
