Name: Zheng, Jian
Degree: Ph.D.
Title: Associate Professor
E-mail: zhengjian@nefu.edu.cn; zhengjian0325@126.com
Education and Training:
2002-2006: Northeast Forestry University, Bachelor of Science in Biology
2006-2009: Northeast Forestry University, Master of Science in cell Biology
2009 - 2013: Northeast Forestry University, Ph.D. in cell Biology
2013 - 2017: Northeast Forestry University, Postdoctoral Training in Biology
2006-2008: Harbin Institute of Technology, Visiting student in Nanomedicine and Biosensor Laboratory
2011-2013: The University of Sydney, Visiting scholar in Pharmacy
Employment:
2013 -2020: Northeast Forestry University, Lecturer
2020 up to now: Northeast Forestry University, Associate Professor
Research Specialty:
Cell Biology; Pharmacy
Courses to Teach:
Cell biology, Developmental biology, Virus and human health
Research Interest:
Transporters; Bioactive compounds; Anti-tumor reagents
Funding:
(1) Fundamental Research Funds for the Central Universities (2572020BD03) (P.I.), 2020-2023
(2) National Natural Science Foundation of China (31800277) (P.I.), 2019-2021
(3) Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province (LBHQ18009) (P.I.), 2018-2020
(4) Scientific Research Foundation of Heilongjiang Province for the Returned Overseas Scholars (LC2015009) (P.I.), 2015-2017
Publications:
1. Qiang Zhang, Ping Zou, Meixuan Zhu, Dan Sui, Shaoming Wang, Zhiwei Hu, Yang Wang, Lijia Jing, Jian Zheng*. Synthesis and biological activity assay of novel camptothecin-peptidic conjugates based on PEPT1. Bioorganic & Medicinal Chemistry Letters, 2023, 96, 129502.
2. Yucen Liang, Meixuan Zhu, Tao Xu, Weimin Ding, Min Chen, Yang Wang, Jian Zheng*. A novel betulinic acid analogue: synthesis, solubility, antitumor activity and pharmacokinetic study in rats. Molecules, 2023, 28, 5715.
3. Jian Zheng, Yong Ji, Changmin Shao, Lijia Jing, Yang Wang. Pharmacokinetics and tissue distribution study of 10-methoxycamptothecin in rats following intragastric administration. Journal of Pharmaceutical and Biomedical Analysis. 2018, 149: 564-571
4. Jian Zheng, Changmin Shao, Bo Fan, Lijia Jing, Siyang Li, Xiufeng Yan, Yang Wang. Synthesis, antitumor activity and pharmacokinetic study of 10-propionyloxy camptothecin in rats. Biomedical Chromatography. 2018;e4336
5. Jian Zheng, Ting Chan, Ling Zhu, Xiufeng Yan, Yang Wang*, Fanfan Zhou*. The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs). Xenobiotica. 2016, 46(9): 831-840.
6. Jian Zheng, Ting Chan, Florence Shin Gee Cheung, Ling Zhu, Michael Murray, Fanfan Zhou*. PDZK1 and NHERF1 regulate the function of human organic anion transporting polypeptide 1A2 (OATP1A2) by modulating its subcellular trafficking and stability. PLoS One. 2014, 9(4): e94712.
7. Jian Zheng, Xiuli Yue, Zhifei Dai, Yang Wang, Shaoqin Liu, Xiufeng Yan, Novel iron–polysaccharide multilayered microcapsules for controlled insulin release, Acta Biomaterialia, 2009, 5: 1499-1507.
8. Jian Zheng, Rui Zhang, Changmin Shao, Zhiwei Hu, Di Wang, Tao Yu, Xiufeng Yan, Yang Wang. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. Journal of Chromatography B, 2012, 903: 81-87.
9. Jian Zheng, Honghong Guo, Na Guo, Wei Ma, Lijia Jing, Rui Zhang, Zhifei Dai, Xiufeng Yan, Yang Wang, Zhenyue Wang. A two-step pH-dependent liquid-liquid extraction combined with HPLC-fluorescence method for the determination of 10-hydroxycamptothecin in mouse liver tissue. Pharmaceutical Biology, 2012, 50(8): 954-961.
10. Shenglei Guo1, Jian Zheng1, Jing Dong, Na Guo, Lijia Jing, Xiuli Yue, Xiufeng Yan, Yang Wang, Zhifei Dai. Iron/dextran sulfate multilayered microcapsules for controlled release of 10-hydroxycamptothecin. International Journal of Biological Macromolecules, 2011, 49: 409-415.
11. Changmin Shao1, Jian Zheng1, Junjie Chi, Lijia Jing, Xiufeng Yan, Yang Wang. Excretion Study of 10-Methoxycamptothecin and Its Metabolite 10-Hydroxycamptothecin in Rats by RP-HPLC Method with Fluorescence Detection. Acta Chromatographica, 2017, 29(4): 453-458
