Name: Shi, Jinming
Degree: Ph.D.
Title: Associate Professor
Phone number: 86-451-8219-1081
E-mail: jmshi@nefu.edu.cn
Address: Northeast Forestry University, Shaw (Yifu) Teaching Building, Room 117
Education and Training:
1997 – 2001: Jilin University, Bachelor of Science in Biochemistry
2001 – 2004: Jilin University, Master of Science in Biochemistry and Molecular Biology
2005 – 2010: Harbin Institute of Technology, Ph.D. in Biology
Employment:
2010 – 2016: Northeast Forestry University, Lecturer
2016 – now: Northeast Forestry University, Associate Professor
Honors and Awards:
2014: First Place in Teaching Competition of Northeast Forestry University
2015: Third prize in Teaching Competition of Heilongjiang Province
Research Specialty:
Molecular Biology, Cancer Biology, Biochemistry
Courses to Teach:
Biochemistry
Biochemical Analysis Technology
Research Interest:
My previous work focused on the anti-radiational effects of bioactive substances. In recent years, my research interest is epigenetic regulation in cancer biology, including functional studies of tumor-related long non-coding RNAs and microRNAs. My previous work showed that miR-15a and miR-16 mediated the expression of FASN, an oncogene that is frequently overexpressed in many kinds of cancer cells and mediates the synthesis of fatty acids as cellular energy resources. We also delineated the molecular mechanism of microRNA-mediated FASN expression and evaluated the prognostic value and therapeutic potential of this regulatory network in breast cancer. Another part of our recent work is to investigate the mechanisms of some natural anti-cancer substance such as ellagic acid in liver cancer and breast cancer.
Funding:
National Natural Science Foundation of Heilongjiang, China (QC2016100) (P.I.)
07/01/2016 – 07/01/2019
Title: Determine the molecular mechanism of miR-15a/16 regulated fatty acid synthase expression and its application in breast cancer diagnosis and therapy
Publications:
Jinming Shi, Aixin Hao, Qiang Zhang, and Guangchao Sui.The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies.(2015)Current Cancer Drug Targets. 15(2):145-157.
http://dx.doi.org/10.2174/1568009615666150131124200
Jinming Shi, Cuilin Cheng, Haitian Zhao, Jing Jing, Ning Gong, Weihong Lu.In vivo anti-radiation activities of the Ulva pertusa polysaccharidesand polysaccharide–iron(III) complex.(2013)International Journal of Biological Macromolecules. 60:341-346.
http://dx.doi.org/10.1016/j.ijbiomac.2013.06.001
Qiang Zhang, Meimei Wan,Jinming Shi, David A. Horita, Lance D. Miller, Timothy E. Kute, Steven J. Kridel, George Kulik, and Guangchao Sui. Yin Yang 1 Promotes mTORC2-mediated AKT Phosphorylation. (2016)J Mol Cell Biol.8(3):232-243.
http://dx.doi.org/doi:10.1093/jmcb/mjw002
Jingxuan Wang, Xiao Zhang,Jinming Shi, Paul Cao, Meimei Wan, Qiang Zhang, Yunxuan Wang, Steven J. Kridel, Wennuan Liu, Jianfeng Xu, Qingyuan Zhang and Guangchao Sui. Fatty Acid Synthase is a Primary Target of MiR-15a and MiR-16-1 in Breast Cancer.Oncotarget. 2016. (in print).
http://dx.doi.org/doi:10.18632/oncotarget.12479
